Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Ran |
| Gene Name: | RAN |
| Protein Full Name: | GTP-binding nuclear protein Ran |
| Alias: | Androgen receptor- associated protein 24; ARA24; Gsp1; GTPase Ran; LPS; Ran GTPase; RAN, member RAS oncogene family; RASL2-8; TC4 |
| Mass (Da): | 24423 |
| Number AA: | 216 |
| UniProt ID: | B5MDF5; A8K3Z8; P62826 |
| Locus ID: | 5901 |
| COSMIC ID: | RAN |
| Gene location on chromosome: | 12q24.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | Small GTPase and Ras family member. Involved in nucleocytoplasmic transport of proteins and RNA, organization of mitotic spindle apparatus and cell cycle control. Associated with apoptosis triggered by DNA damage and microtubule-emanating signals, although function is not fully understood. Reported to interact with the tumour suppressor RASSF1. Expression of RAN is upregulated in various human tumors and cancer cell lines. |
| Commentary on involvement of protein in cancer: | No mutations have been reported on the SANGER COSMIC database or the Atlas of Oncology. |