Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Rap1a |
| Gene Name: | RAP1A |
| Protein Full Name: | Ras-related protein Rap-1A |
| Alias: | C21KG; G-22K; GTP-binding protein SMG-P21A; KREV1; KREV-1; RAP1A, member of RAS oncogene family; RAPA; Ras-related protein Rap-1A; SMGP21 |
| Mass (Da): | 20987 |
| Number AA: | 184 |
| UniProt ID: | P62834; A8KAH9; Q5U0C3 |
| Locus ID: | 5906 |
| COSMIC ID: | RAP1A |
| Gene location on chromosome: | 1p13.3 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | RAP1A belongs to the family of RAS-related proteins and has been found to counteract the mitogenic function of RAS due to its ability to interact with RAS GAPs and RAF in a competitive manner, and may thus function as a tumour suppressor. However, it has not been implicated in any pathologies yet. |