Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BLCAP |
| Gene Name: | BLCAP |
| Protein Full Name: | Bladder cancer-associated protein |
| Alias: | Bladder cancer 10 kDa protein |
| Mass (Da): | 9876 |
| Number AA: | 87 |
| UniProt ID: | P62952 |
| Locus ID: | 10904 |
| COSMIC ID: | BLCAP |
| Gene location on chromosome: | 20q11.23 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | BLCAP induces apoptosis, S-phase arrest, and decreased cell proliferation. Growth inhibition was correlated with up-regulation of p21 (WAF1/CIP1 ) expression and down-regulation of Bcl-XL and Bcl-2 expressions. Downregulation has been empirically demonstrated in bladder cancer systems as well as other tumors. |