Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SKP1 |
| Gene Name: | SKP1 |
| Protein Full Name: | S-phase kinase-associated protein 1 |
| Alias: | Cyclin A/CDK2-associated p19; EMC19; OCP2; OCP-2; OCP-II; Organ of Corti 2; P19A; P19skp1; RNA polymerase II elongation factor-like; SIII; SKP1; TCEB1L; Transcription elongation factor B (SIII), polypeptide 1-like |
| Mass (Da): | 18658 |
| Number AA: | 163 |
| UniProt ID: | P63208 |
| Locus ID: | 6500 |
| COSMIC ID: | SKP1 |
| Gene location on chromosome: | 5q31 |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.1 |
| Commentary on involvement of protein in cancer: | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110. |