Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TMSB10 |
| Gene Name: | TMSB10 |
| Protein Full Name: | Thymosin beta-10 |
| Alias: | MIG12; Migration-inducing gene 12; Migration-inducing protein 12; PTMB10; TB10; THYB10; Thymosin beta 10; Thymosin, beta 10; TYB10 |
| Mass (Da): | 5026 |
| Number AA: | 44 |
| UniProt ID: | P63313 |
| Locus ID: | 9168 |
| COSMIC ID: | TMSB10 |
| Gene location on chromosome: | 2p11.2 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.05 |
| Normal role description: | TMSB10 plays an important role in the organization of the cytoskeleton by binding to and sequestering G-actin monomers in a 1:1 complex and thereby inhibits actin polymerization and regulates cancer cell motility. It also plays an important role in early neuroembryogenesis, and is involved in the development of the oral cavity and its annexes. TMSB10 is involved in cell apoptosis possibly by acting as an actin-mediated tumour suppressor, and it also functions as a potent inhibitor of angiogenesis and tumour growth by interactions with Ras. However, elevated expressions of TMSB10 have been associated with invasion and metastasis of various tumours, with the intensity of staining in cancerous cells being proportionally increased with the increasing grade of the lesions. |