Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | YBX1 |
| Gene Name: | YBX1 |
| Protein Full Name: | Nuclease-sensitive element-binding protein 1 |
| Alias: | BP-8; CBF-A; CCAAT-binding transcription factor I subunit A; CSDA2; CSDB; DBPB; DNA-binding protein B; EFI-A; Enhancer factor I subunit A; MDR-NF1; MSY-1; NSEP1; NSEP-1; Nuclease sensitive element binding protein 1; Y box binding protein 1; Y box binding protein-1; YB1; Y-box transcription factor; YBOX1; Y-box-binding protein 1 |
| Mass (Da): | 35924 |
| Number AA: | 324 |
| UniProt ID: | P67809 |
| Locus ID: | 4904 |
| COSMIC ID: | YBX1 |
| Gene location on chromosome: | 1p34.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19745 |
| Percent of cancer specimens with mutations: | 0.31 |
| Normal role description: | YBX1 is involved in chromatin remodeling, mismatch DNA repair, transcriptional regulation, pre-mRNA splicing regulation, translation and stress response. YBX1 is overexpressed and localized in the nucleus in cancers and promote drug resistace by increasing transcription of MDR1 and other genes associated with proliferation and invasion. |