Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TPM4 |
| Gene Name: | TPM4 |
| Protein Full Name: | Tropomyosin alpha-4 chain |
| Alias: | Tropomyosin-4 |
| Mass (Da): | 28522 |
| Number AA: | 248 |
| UniProt ID: | P67936 |
| Locus ID: | 7171 |
| COSMIC ID: | TPM4 |
| Gene location on chromosome: | 19p13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19895 |
| Percent of cancer specimens with mutations: | 0.02 |
| Deregulated in translocations: | ALK |
| Normal role description: | TPM4 is an actin binding protein that is involved in contraction of striated and smooth muscle and stabilizing actin filaments in non muscle cells. Translocations events creates a constituitively active fusion protein that can mediate oncogenesis. |