Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LCN2 |
| Gene Name: | LCN2 |
| Protein Full Name: | Neutrophil gelatinase-associated lipocalin |
| Alias: | 25 kDa alpha-2-microglobulin-related subunit of MMP-9; HNL; Lipocalin 2; Lipocalin-2; NGAL; Oncogene 24p3; p25 |
| Mass (Da): | 22588 |
| Number AA: | 198 |
| UniProt ID: | P80188 |
| Locus ID: | 3934 |
| COSMIC ID: | LCN2 |
| Gene location on chromosome: | 9q34 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.18 |
| Commentary on involvement of protein in cancer: | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |