Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ADAMTSL3 |
| Gene Name: | ADAMTSL3 |
| Protein Full Name: | ADAMTS-like protein 3 |
| Alias: | a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3; ADAMTS-like 3; ATL3; KIAA1233; punctin-2 |
| Mass (Da): | 188640 |
| Number AA: | 1691 |
| UniProt ID: | P82987 |
| Locus ID: | 57188 |
| COSMIC ID: | ADAMTSL3 |
| Gene location on chromosome: | 15q25.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20344 |
| Percent of cancer specimens with mutations: | 2.11 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many point mutations across entire protein, but no complex mutations, insertions or deletions. |
| Normal role description: | ADAMTSL3 is poorly characterized, though it is known that it contains: Contains 3 Ig-like C2-type (immunoglobulin-like) domains, 1 PLAC domain, and 10 TSP type-1 domains; additionally, unlike other members of of the ADAMTS family, it does not have the metalloprotease and disintegrin-like domains. Missense mutations in ADAMTSL3 are common in colon cancer; however, it's expression is usually decreased relative to normal colon tissue, thus it may constitute a tumour suppressor protein (TSP), as loss of its function is associated colon cancer. |
| Commentary on involvement of protein in cancer: | Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon. |