Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: Shc2
Gene Name: SHC2
Protein Full Name: SHC-transforming protein 2
Alias: Sck; SH2 domain protein C2; SHCB; Src homology 2 domain-containing transforming protein C2
Mass (Da): 61916
Number AA: 582
UniProt ID: P98077
Locus ID: 25759
COSMIC ID: SHC2
Gene location on chromosome: 19p13.3
Number of cancer specimens: 19884
Percent of cancer specimens with mutations: 0.4
Commentary on involvement of protein in cancer: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons 


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