Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARHGAP4 |
| Gene Name: | ARHGAP4 |
| Protein Full Name: | Rho GTPase-activating protein 4 |
| Alias: | C1; KIAA0131; P115; RGC1; RHG04; Rho GTPase activating protein 4; Rho-GAP hematopoietic protein C1; RHOGAP4 |
| Mass (Da): | 105026 |
| Number AA: | 946 |
| UniProt ID: | P98171 |
| Locus ID: | 393 |
| COSMIC ID: | ARHGAP4 |
| Gene location on chromosome: | 2Q22 |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.62 |
| Normal role description: | Inhibits stress fiber activation and also Rho-like GTPase in hematopoetic cells. Although co-deletion has been associated with the AVPR2 and nephrogenic diabetes insipidus, no oncogenic phenotype was reported suggesting that loss of function is compensated by alternate cell signalling pathways. |