Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FOXO4 |
| Gene Name: | FOXO4 |
| Protein Full Name: | Forkhead box protein O4 |
| Alias: | Afx; Afx1; Afxh; Forkhead box O4; Forkhead domain AFX1; Foxo4; Mllt7; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Translocated to, 7 (AFX1) |
| Mass (Da): | 53684 |
| Number AA: | 505 |
| UniProt ID: | P98177 |
| Locus ID: | 4303 |
| COSMIC ID: | FOXO4 |
| Gene location on chromosome: | Xq13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20145 |
| Percent of cancer specimens with mutations: | 0.43 |
| Deregulated in translocations: | Acute leukemias. Fusion partners include MLL |
| Normal role description: | Transcription of proteins involve in cell growth and differentiation. |