Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CLTC |
| Gene Name: | CLTC |
| Protein Full Name: | Clathrin heavy chain 1 |
| Alias: | Clathrin heavy chain; Clathrin, heavy chain; Clathrin, heavy polypeptide (Hc); CLH; CLH1; CLH17; CLH-17; CLTCL2; Hc; KIAA0034 |
| Mass (Da): | 191615 |
| Number AA: | 1675 |
| UniProt ID: | Q00610 |
| Locus ID: | 1213 |
| COSMIC ID: | CLTC |
| Gene location on chromosome: | 17q23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 1 |
| Deregulated in translocations: | t(2;17)(p23;q23): ALK - CLTC; t(X;17)(p11;q23): CLTC-TFE3 |
| Normal role description: | The major protein component of the cytoplasmic face of intracellular organelles (coated vesicles, coated pits) is Clathrin. It is involved in receptor-mediated endocytosis and intracellular trafficking and consists of three heavy and three light chains. Two different adaptor protein complexes link clathrin to the trans-Golgi network or plasma membrane. |