Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NFKB2 |
| Gene Name: | NFKB2 |
| Protein Full Name: | Nuclear factor NF-kappa-B p100 subunit |
| Alias: | DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10; LYT-10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); Oncogene Lyt-10; P52 |
| Mass (Da): | 96749 |
| Number AA: | 900 |
| UniProt ID: | Q00653 |
| Locus ID: | 4791 |
| COSMIC ID: | NFKB2 |
| Gene location on chromosome: | 10q24 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20289 |
| Percent of cancer specimens with mutations: | 0.44 |
| Deregulated in translocations: | t(10;14)(q24;q11) or t(10;14)(q24;q32) in hematological malignancies. Fusion partners include Calpha1. |
| Normal role description: | NFKB2 is a transcription factor that plays a role in regulating a diveristy of gene, including those involved in: immunity, stress responses, apoptosis, and differentiation. NFKB2 can from as a fusion protein formed by is translocation,t(10;14)(q24;q32), next to the C alpha 1 immunoglobulin locus, as well as the translocation,t(10;14)(q24;q11); both of these translocations have been found in hematological malignacies. |