Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: PLCB2
Gene Name: PLCB2
Protein Full Name: 1-phosphatidylinositol-4,5-bisphosphate phosphodie
Alias: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2; FLJ38135; Phosphoinositide phospholipase C; Phospholipase C- beta-2; Phospholipase C, beta 2; PLC-beta-2
Mass (Da): 134024
Number AA: 1185
UniProt ID: Q00722
Locus ID: 5330
COSMIC ID: PLCB2
Gene location on chromosome: 15q15
Cancer protein type: OP
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: PROMOTES
Number of cancer specimens: 19850
Percent of cancer specimens with mutations: 0.87
Normal role description: This phospholipase is activated by trimeric G-protein subunits and generates DAG and IP3 from PIP2. Therefore, PLCB2 generates important second messengers in cellular signalling. Analysis of breast cancer tumors demonstrates that increasing PLCB2 expression correlates with loss of differentiation and worse prognosis. This supports the theory that proteins downstream of the IP3/DAG signalling pathway promote oncogenesis.


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