Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FLI1 |
| Gene Name: | FLI1 |
| Protein Full Name: | Friend leukemia integration 1 transcription factor |
| Alias: | ERGB transcription factor; EWSR2; Fli-1 proto-oncogene; Friend leukemia virus integration 1; SIC-1; Transcription factor ERGB |
| Mass (Da): | 50982 |
| Number AA: | 452 |
| UniProt ID: | Q01543 |
| Locus ID: | 2313 |
| COSMIC ID: | FLI1 |
| Gene location on chromosome: | 11q24.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20297 |
| Percent of cancer specimens with mutations: | 0.64 |
| Deregulated in translocations: | Ewing sarcoma and primitive neuroectodermal tumors, Fusion partners include EWS1; Acute Myelogenous Leukemia, Fusion partners include tel |
| Transduced into viral genome: | Friend Murine Leukemia virus- Murine; 10A1, Cas-Be-E - Murine; |
| Normal role description: | Plays an important role in erythropoiesis, |