Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | XPC |
| Gene Name: | XPC |
| Protein Full Name: | DNA repair protein complementing XP-C cells |
| Alias: | DNA repair protein complementing XP-C cells: Xeroderma pigmentosum group C-complementing protein: p125; DNA-repair protein complementing XP-C cells; P125; RAD4; Xeroderma pigmentosum group C complementing protein; Xeroderma pigmentosum group C protein; Xeroderma pigmentosum, complementation group C; XPCC |
| Mass (Da): | 105981 |
| Number AA: | 940 |
| UniProt ID: | Q01831 |
| Locus ID: | 7508 |
| COSMIC ID: | XPC |
| Gene location on chromosome: | 3p25 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20443 |
| Percent of cancer specimens with mutations: | 0.54 |
| Mutations observed as inherited: | Xeroderma pigmentosum (XP). |
| Normal role description: | DNA repair helicase, nucleotide excision repair. |