Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | POU4F1 |
| Gene Name: | POU4F1 |
| Protein Full Name: | POU domain, class 4, transcription factor 1 |
| Alias: | Brn3a; Oct-t1; Po4f1; Pou class 4 homeobox 1; Pou domain, class 4, transcription factor 1; Pou4f1; Rdc-1 |
| Mass (Da): | 42754 |
| Number AA: | 420 |
| UniProt ID: | Q01851 |
| Locus ID: | 5457 |
| COSMIC ID: | POU4F1 |
| Gene location on chromosome: | 13q31.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.36 |
| Normal role description: | POU4F1 is a transcriptional regulator involved in cell fate determination, differentiation of neuronal cells, generation of proprioceptors in trigeminal ganglia, induce cell cycle arrest, regulate p53 activity, promote surivavl signals and down regulate pro-apoptotic signals. It can also activate HPV E6/E7 protein. It is overexpressed in many cancers and prevents apoptosis and promotes survival of tumours. |