Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC6A3 |
| Gene Name: | SLC6A3 |
| Protein Full Name: | Sodium-dependent dopamine transporter |
| Alias: | DA transporter; DAT1; Dopamine transporter; S6A3; SC6A3; Solute carrier family 6 (neurotransmitter transporter, dopamine) member 3; Solute carrier family 6 member 3 |
| Mass (Da): | 68495 |
| Number AA: | 620 |
| UniProt ID: | Q01959 |
| Locus ID: | 6531 |
| COSMIC ID: | SLC6A3 |
| Gene location on chromosome: | 5p15.3; 5p15.33 |
| Number of cancer specimens: | 19699 |
| Percent of cancer specimens with mutations: | 1.04 |
| Normal role description: | Aberrant expression of SLC39A6 has been observed in pancreatic, breast and cervical cancers. Reduced expression of SLC39A6 is observed in more malignant breast cancer while increased expression is implicated in pancreatic cancer. The function of SLC39A6 appears to be mixed in different tissue types. |