Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ROR1 |
| Gene Name: | ROR1 |
| Protein Full Name: | Tyrosine-protein kinase transmembrane receptor ROR |
| Alias: | EC 2.7.1.112; EC 2.7.10.1; NTRKR1 |
| Mass (Da): | 104283 |
| Number AA: | 937 |
| UniProt ID: | Q01973 |
| Locus ID: | 4919 |
| COSMIC ID: | ROR1 |
| Gene location on chromosome: | 1p31.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20751 |
| Percent of cancer specimens with mutations: | 0.85 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ROR1 is a receptor tyrosine kinase that plays a role in neurite growth in the CNS. Its role as a protein is poorly understood and its function in cancer has yet to be elucidated, but several mutations have been associated with various cancers. |