Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TEK |
| Gene Name: | TEK |
| Protein Full Name: | Angiopoietin-1 receptor |
| Alias: | Angiopoietin 1 receptor; CD202b antigen; EC 2.7.10.1; HYK; P140 TEK; TEK |
| Mass (Da): | 125811 |
| Number AA: | 1124 |
| UniProt ID: | Q02763 |
| Locus ID: | 7010 |
| COSMIC ID: | TEK |
| Gene location on chromosome: | 9p21.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20797 |
| Percent of cancer specimens with mutations: | 1.01 |
| Normal role description: | TEK is a receptor tyrosine kinase. It is expressed on endothelial cells and is involved in cell-smooth muscle cell communication, venous morphogenesis, angiogenesis and vessel remodeling. It is also implicated in cell surival, cell migration and adhesion to cells and matrix. Overexpression is associated with many cell types and promote angiogenesis. |