Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP3K10 |
| Gene Name: | MAP3K10 |
| Protein Full Name: | Mitogen-activated protein kinase kinase kinase 10 |
| Alias: | EC 2.7.11.25; Kinase MLK2; M3K10; MAP3K10; MEKK10; Mitogen-activated protein kinase kinase kinase 10; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MST; Protein kinase MST |
| Mass (Da): | 103623 |
| Number AA: | 954 |
| UniProt ID: | Q02779 |
| Locus ID: | 4294 |
| COSMIC ID: | MAP3K10 |
| Gene location on chromosome: | 19q13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20473 |
| Percent of cancer specimens with mutations: | 0.7 |
| Normal role description: | MAP3K10 is a protein-serine/threonine kinase involved in the JNK signalling pathway leading to c-Jun activation. MAP3K10 will activate JNK by phosphorylation. JNK signalling is found to promote apoptosis, neurodegeneration, cell differentiation and inflammation. As MAP3K10 is an important mediator of the pro-apoptotic JNK signalling pathway it may have a role as a tumour supressor protein. Mis-sense mutations have been observed in metastatic melanomas but have not been characterized functionally. |