Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MUC2 |
| Gene Name: | MUC2 |
| Protein Full Name: | Mucin-2 |
| Alias: | intestinal mucin-2; MLP; mucin 2, intestinal/tracheal; mucin 2, oligomeric mucus/gel-forming; mucin-2; mucin-like; SMUC |
| Mass (Da): | 540300 |
| Number AA: | 5179 |
| UniProt ID: | Q02817 |
| Locus ID: | 4583 |
| COSMIC ID: | MUC2 |
| Gene location on chromosome: | 11p15.5 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 7055 |
| Percent of cancer specimens with mutations: | 2.74 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations and 1 deletion, but no complex mutations or insertions. |
| Normal role description: | MUC2 is the mucin layer that coats the Gastroinestinal tract, airways and other mucosal surfaces. It provides lubrication and protection from external particles and pathogens at the mucosal surface. Loss of MUC2 increases risk of oncogenesis by lack of protecting against bacteria or particles with pro-oncogenic properties, or disrupting signalling within epithelial cells that require MUC2 for proliferation and differentiation. |