Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TOP2B |
| Gene Name: | TOP2B |
| Protein Full Name: | DNA topoisomerase 2-beta |
| Alias: | EC 5.99.1.3; Topoisomerase (DNA) II beta 180kDa; TP2B; TPB2 |
| Mass (Da): | 183267 |
| Number AA: | 1626 |
| UniProt ID: | Q02880 |
| Locus ID: | 7155 |
| COSMIC ID: | TOP2B |
| Gene location on chromosome: | 3p24.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19763 |
| Percent of cancer specimens with mutations: | 0.81 |
| Commonly recorded point mutations: | R312G (7) |
| Normal role description: | TOP2B is a DNA topoisomerase enzyme and regulates chromatin remodeling and relieving topological stresses from DNA during replication and transcription. This involves creating breaks in the strand and rejoining them. In prostate cancer it is involved in creating gene rearrangements |