Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AKAP12 |
| Gene Name: | AKAP12 |
| Protein Full Name: | A-kinase anchor protein 12 |
| Alias: | A kinase (PRKA) anchor protein 12; AKA12; AKAP250; Gravin; Myasthenia gravis autoantigen gravin; RP11-351K16.7-001; SSeCKS |
| Mass (Da): | 191483 |
| Number AA: | 1782 |
| UniProt ID: | Q02952 |
| Locus ID: | 9590 |
| COSMIC ID: | AKAP12 |
| Gene location on chromosome: | 6q25 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 1.37 |
| Gene undergoes hypermethylation: | Gastric cancer,Barrtt's associated esophageal neoplasm, |
| Normal role description: | AKAP12 recruits PKA, PKC, and phosphatases to localized areas within the cell compartment and facilitates in signal transduction. It is found to be involved in blood-brain barrier differentiation regulation, brain angiogenesis and tight junction formation. In cancers, its expression is inhibited via hypermethylation or other means to induce progression of disease. |