Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Pax2 |
| Gene Name: | PAX2 |
| Protein Full Name: | Paired box protein Pax-2 |
| Alias: | paired box 2; PAX-2 |
| Mass (Da): | 44706 |
| Number AA: | 417 |
| UniProt ID: | Q02962 |
| Locus ID: | 5076 |
| COSMIC ID: | PAX2 |
| Gene location on chromosome: | 10q24 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.38 |
| Normal role description: | PAX2 is a nuclear localized transcription factor. PAX2 may have a role in the development of kidney, CNS and eyes through regulating cellular differentiation and proliferation. Overexpression of PAX2 has been detected in kidney, prostate, breast and ovarian cancer. Hypomethylation of the PAX2 promoter caused by estrogen has been observed in endometrial cancer. PAX2 appears to function as an oncogene is the development of cancer. |