Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DST |
| Gene Name: | DST |
| Protein Full Name: | Dystonin |
| Mass (Da): | 624997 |
| Number AA: | 5457 |
| UniProt ID: | Q03001 |
| Locus ID: | 667 |
| COSMIC ID: | DST |
| Gene location on chromosome: | 6p12.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19831 |
| Percent of cancer specimens with mutations: | 1.63 |
| Normal role description: | Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cell (UniProt). Mice defective for this gene show skin blistering and neurodegeneration. Role in oncogenesis unclear - may function to regulate metastatic potential. |