Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MLLT1 |
| Gene Name: | MLLT1 |
| Protein Full Name: | Protein ENL |
| Alias: | ENL; LTG19; Myeloid/lymphoid or mixed-lineage leukemia (trithorax); Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 1; Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 1 (ENL); YEATS domain-containing protein 1; YEATS1 |
| Mass (Da): | 62056 |
| Number AA: | 559 |
| UniProt ID: | Q03111 |
| Locus ID: | 4298 |
| COSMIC ID: | MLLT1 |
| Gene location on chromosome: | 19p13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.42 |
| Deregulated in translocations: | t(11.19)(q23;p13.3) creates a fusion gene (5' MLL - 3' ENL) and contributes to myeloid/lymphoid or mixed lineage leukemias (MLL) |
| Normal role description: | MLLT1 is a fusion protein created by a translocation and is thought to be able to activate transcription in both lymphoid and myeloid cells. MLLT1 contributes to myeloid/lymphoid or mixed lineage leukemias (MLL). |