Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPARD |
| Gene Name: | PPARD |
| Protein Full Name: | Peroxisome proliferator-activated receptor delta |
| Alias: | NR1C2; NUC1; NUCI; Nuclear hormone receptor 1; PPAR- beta; PPARB; PPAR-delta |
| Mass (Da): | 49903 |
| Number AA: | 441 |
| UniProt ID: | Q03181 |
| Locus ID: | 5467 |
| COSMIC ID: | PPARD |
| Gene location on chromosome: | 6p21.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | Transcription factor that is activated by binding of ligands, such as peroxisome proliferators (hypolipidemic drugs and fatty acids). Activated PPARD binds to promotor regions of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. PPARD is highly expressed in the gastrointestinal tract in a constitutive manner where it regulates cell proliferation and differentiation. Wnt/beta-catenin stimulates PPARD expression and COX2 pathway results in activation of PPARD via PI3K-Akt pathway. Overexpression is associated with colon cancers. |