Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PLAUR |
| Gene Name: | PLAUR |
| Protein Full Name: | Urokinase plasminogen activator surface receptor |
| Alias: | Monocyte activation antigen Mo3 |
| Mass (Da): | 36978 |
| Number AA: | 335 |
| UniProt ID: | Q03405 |
| Locus ID: | 5329 |
| COSMIC ID: | PLAUR |
| Gene location on chromosome: | 19q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.39 |
| Normal role description: | Interacts with the serine protease urokinase-type plasminogen activator. The plasminogen activator urokinase receptor (PLAUR) plays a central role in cell surface-associated plasminogen activation and proteolytic degradation of the ECM. This is important in wound healing and other tissue remodeling processes. PLAUR is often found to be expressed at the invasive front of cancer tissue and is implicated in metastasis and invasion. |