Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RELA |
| Gene Name: | RELA |
| Protein Full Name: | Transcription factor p65 |
| Alias: | NFKB3; Nuclear factor NF-kappa-B p65 subunit; P65; RELA; TF65; V-rel reticuloendotheliosis viral oncogene A |
| Mass (Da): | 60219 |
| Number AA: | 551 |
| UniProt ID: | Q04206 |
| Locus ID: | 5970 |
| COSMIC ID: | RELA |
| Gene location on chromosome: | 11q12-q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20363 |
| Percent of cancer specimens with mutations: | 0.41 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | head/neck squamous carcinomas, breast/stomach adenocarcinomas |
| Deregulated in translocations: | t(11;14)(q14;q32) in lymphoproliferative disorders |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | reticuloendotheliosis virus (avian) |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | RELA is a transcription factor also known as NF-kB p65 subunit. The NF-kB/p65 has been shown to be constitutively activated in prostate adenocarcinomas and may promote tumour progression by upregulating the transcription of NF-kB target genes and promoting anti-apoptosis activity. A t(11;14)(q14;q32) translocation involving p65 gene rearrangement has been described in lymphoproliferative disporders. Gene amplification has also been observed in squamous carcinomas of head and neck as well as breast and stomach adenocarcinomas. |