Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EIF4G1 |
| Gene Name: | EIF4G1 |
| Protein Full Name: | Eukaryotic translation initiation factor 4 gamma 1 |
| Alias: | EIF4F; EIF4G; EIF-4G; EIF-4G 1; EIF-4G1; EIF-4-gamma 1; EIF4GI; Eukaryotic translation initiation factor 4 gamma, 1; Eukaryotic translation initiation factor 4GI; IF4G1; P220 |
| Mass (Da): | 175535 |
| Number AA: | 1600 |
| UniProt ID: | Q04637 |
| Locus ID: | 1981 |
| COSMIC ID: | EIF4G1 |
| Gene location on chromosome: | 3q27.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19876 |
| Percent of cancer specimens with mutations: | 1.37 |
| Found in amplified chromosomal regions in human cancers: | Squamous cell lung carcinomas (30%) |
| Normal role description: | eIF4G1 is a component of the EIF4F complex which recruits mRNA to ribosomes to initiate translation. eIF4G1 functions primarily as a scaffold to recruit subunits of the complex and maintain complex integrity. eIF4G1 can also interact with poly(A)-binding protein to mediate circularization of mRNA during translation. Amplification of eIF4G1 has been observed in squamous cell lung carcinomas, while silencing of eIF4G1 in breast cancers have reduced tumorigenic potential in a breast cancer cell line. eIF4G1 overexpression may be a mechanism required for cancer development as protein translation is required for cell growth and proliferation. |
| Commentary on involvement of protein in cancer: | Less than 3% mutation in CNS and lung. |