Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MST1R |
| Gene Name: | MST1R |
| Protein Full Name: | Macrophage-stimulating protein receptor |
| Alias: | CD136; CD136 antigen; CDW136; C-met-related tyrosine kinase; EC 2.7.10.1K; Kinase RON; Macrophage stimulating 1 receptor; Macrophage-stimulating protein receptor precursor; MSP receptor; MST1R; P185-Ron; PTK8; RON; ST; Stem cell-derived tyrosine kinase; STK |
| Mass (Da): | 152227 |
| Number AA: | 1400 |
| UniProt ID: | Q04912 |
| Locus ID: | 4486 |
| COSMIC ID: | MST1R |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20660 |
| Percent of cancer specimens with mutations: | 0.94 |
| Normal role description: | MST1R is a receptor-tyrosine kinase that is activated upon binding macrophage stimulating 1 factor. Homolog to the MET RTK oncogene and implicated in cancer via similar intracellular signalling pathways. |