Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SRY |
| Gene Name: | SRY |
| Protein Full Name: | Sex-determining region Y protein |
| Alias: | Testis-determining factor |
| Mass (Da): | 23884 |
| Number AA: | 204 |
| UniProt ID: | Q05066 |
| Locus ID: | 6736 |
| COSMIC ID: | SRY |
| Gene location on chromosome: | Yp11.3 |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.06 |
| Commentary on involvement of protein in cancer: | Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells By similarity. In male adult brain involved in the maintenance of motor functions of dopaminergic neuronsBy similarity. Involved in different aspects of gene regulation including promoter activation or repression By similarity. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. |