Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EEF1A2 |
| Gene Name: | EEF1A2 |
| Protein Full Name: | Elongation factor 1-alpha 2 |
| Alias: | EEF1A-2; EEF1AL; EF12; EF1A2; EF-1-alpha-2; Elongation factor 1 A-2; Eukaryotic translation elongation factor 1 alpha 2; HS1; Statin S1; STN; STNL |
| Mass (Da): | 50470 |
| Number AA: | 463 |
| UniProt ID: | Q05639 |
| Locus ID: | 1917 |
| COSMIC ID: | EEF1A2 |
| Gene location on chromosome: | 20q13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19629 |
| Percent of cancer specimens with mutations: | 0.69 |
| Normal role description: | Encodes for isoform 2 of the alpha subunit of the elongation factor-1 complex (eEF1A). eEF1A recruits amino-acylated tRNA to the ribosome. eEF1A2 activates Akt and stimulates phosphatidylinositol 4-kinase beta. Implicated in actin remodeling. Promotes cell migration and invasion. Overexpression in breast, ovarian and lung tumors. |