Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRKCD |
| Gene Name: | PRKCD |
| Protein Full Name: | Protein kinase C delta type |
| Alias: | nPKC-delta |
| Mass (Da): | 77487 |
| Number AA: | 676 |
| UniProt ID: | Q05655 |
| Locus ID: | 5580 |
| COSMIC ID: | PRKCD |
| Gene location on chromosome: | 3p21.1 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20449 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | PRKCD is a protein-serine/threonine kinase. It is involved in promoting apoptosis, differentiation of cell types, cell growth, regulation of transcription factors, NFkB signalling induced by reactive oxygen species, and antigen presentation. Overexpression is seen in breast cancer and is associated with tamoxifen resistance. Reduced expression in MCF-7 cells is associated with a metastatic phenotype. |