Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TJP1 |
| Gene Name: | TJP1 |
| Protein Full Name: | Tight junction protein ZO-1 |
| Alias: | DKFZp686M05161; MGC133289; Tight junction protein 1; Tight junction protein 1 (zona occludens 1); Tight junction protein ZO-1; ZO-1; Zona occludens 1; Zona occludens protein 1; Zonula occludens 1; Zonula occludens protein 1 |
| Mass (Da): | 195459 |
| Number AA: | 1748 |
| UniProt ID: | Q07157 |
| Locus ID: | 7082 |
| COSMIC ID: | TJP1 |
| Gene location on chromosome: | 15q13.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 1.27 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | TJP1 is a protein required for tight junction assembly and function. It regulates cell migration by targeting CDC42BPB to the leading edge of migrating cells, thus promoting motility. Its function in cancer is not well understood. |