Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: ZFP36L1
Gene Name: ZFP36L1
Protein Full Name: Zinc finger protein 36, C3H1 type-like 1
Alias: BERG36; CMG1; EGF-response factor 1; ERF1; ERF-1; Protein TIS11B; RNF162B; TIS11B; TIS11B protein; TISB; Zinc finger protein 36, C3H type-like 1
Mass (Da): 36314
Number AA: 338
UniProt ID: Q07352
Locus ID: 677
COSMIC ID: ZFP36L1
Gene location on chromosome: 14q24.1
Cancer protein type: UNCLEAR
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: UNCLEAR
Number of cancer specimens: 19625
Percent of cancer specimens with mutations: 0.42
Deregulated by viral insertion: Human T-lymphotropic virus 1(HTLV-1)
Normal role description: ZFP36L1 may be involved in VEGF mRNA regulation. It binds and deandenylates mRNA to destabilize it. It may also function as a pro-apoptotic protein. Its expression is increasded in many cancers.


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