Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DPT |
| Gene Name: | DPT |
| Protein Full Name: | Dermatopontin |
| Alias: | Tyrosine-rich acidic matrix protein |
| Mass (Da): | 24005 |
| Number AA: | 201 |
| UniProt ID: | Q07507 |
| Locus ID: | 1805 |
| COSMIC ID: | DPT |
| Gene location on chromosome: | 1q24.2 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.22 |
| Normal role description: | Mediates adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. |