Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNK2 |
| Gene Name: | TNK2 |
| Protein Full Name: | Activated CDC42 kinase 1 |
| Alias: | ACK; ACK1; Activated Cdc42-associated kinase 1; Activated p21cdc42Hs kinase; Activated p21cdc42Hs kinase 1; EC 2.7.10.2; Kinase ACK1; Non-receptor protein tyrosine kinase Ack; P21cdc42Hs; Tyrosine kinase, non-receptor, 2 |
| Mass (Da): | 114569 |
| Number AA: | 1038 |
| UniProt ID: | Q07912 |
| Locus ID: | 10188 |
| COSMIC ID: | TNK2 |
| Gene location on chromosome: | 3q29 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20028 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | TNK2 is a non-receptor tyrosine- and serine/threonine-kinase. It is implicated in numerous roles, including: cell spreading and migration, cell survival, cell growth, and proliferation. TNK2 is known to phosphorylate: AKT1, AR, MCF2, WASL and WWOX. In this capacity TNK2 negatively regulates the tumour suppressor, WWOX, while activating the oncoproteins, AKT1 and AR. Mutations in this gene have been observed in ovarian, skin, and stomach tumors. |