Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FOXM1 |
| Gene Name: | FOXM1 |
| Protein Full Name: | Forkhead box protein M1 |
| Alias: | FKH16; FKHL16; Forkhead box M1; Forkhead homolog 16; Forkhead-related protein FKHL16; FXM1; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH11; HFH-11; HNF-3; HNF-3/fork-head homolog-11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP2; TGT3; Transcription factor Trident; Trident; WIN; Winged helix factor from INS-1 cells; Winged-helix factor from INS-1 cells; Winged-helix transcription factor Trident |
| Mass (Da): | 84283 |
| Number AA: | 763 |
| UniProt ID: | Q08050 |
| Locus ID: | 2305 |
| COSMIC ID: | FOXM1 |
| Gene location on chromosome: | 12p13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | FOXM1 is a transcriptional activator that regulates expression of G2-M cell cycle genes, DNA replication and mitosis genes. It also plays a role in cell proliferation control and DNA break repair in the DNA damage checkpoint response. It is often upregulated in cancer to promote cell proliferation and cancer progression |