Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RGS1 |
| Gene Name: | RGS1 |
| Protein Full Name: | Regulator of G-protein signaling 1 |
| Alias: | B-cell activation protein BL34;Early response protein 1R20 |
| Mass (Da): | 23858 |
| Number AA: | 209 |
| UniProt ID: | Q08116 |
| Locus ID: | 5996 |
| COSMIC ID: | RGS1 |
| Gene location on chromosome: | 1q31 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.35 |
| Commonly recorded point mutations: | N79K (8) |
| Normal role description: | G protein regulator - GTPase stimulator. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. |
| Commentary on involvement of protein in cancer: | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. |