Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DHX9 |
| Gene Name: | DHX9 |
| Protein Full Name: | ATP-dependent RNA helicase A |
| Alias: | DDX9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH-box protein 9; LKP; NDH II; NDH2; Nuclear DNA helicase II; RHA |
| Mass (Da): | 140958 |
| Number AA: | 1270 |
| UniProt ID: | Q08211 |
| Locus ID: | 1660 |
| COSMIC ID: | DHX9 |
| Gene location on chromosome: | 1q25.3 |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.9 |
| Normal role description: | DHX9 catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. It functions as a transcriptional activator. It is found upregulated in lung cancer and has been implicated in breast cancer. |
| Commentary on involvement of protein in cancer: | Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. |