Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MN1 |
| Gene Name: | MN1 |
| Protein Full Name: | Probable tumor suppressor protein MN1 |
| Alias: | Meningioma (disrupted in balanced translocation) 1; MGCR1-PEN; Probable tumor suppressor protein MN1; Tumor suppressor protein MN1; Tumour suppressor protein MN1 |
| Mass (Da): | 136001 |
| Number AA: | 1320 |
| UniProt ID: | Q10571 |
| Locus ID: | 4330 |
| COSMIC ID: | MN1 |
| Gene location on chromosome: | 22q11-12 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20930 |
| Percent of cancer specimens with mutations: | 1.08 |
| Deregulated in translocations: | t(12;22)(p13;q11): MN1-ETV6 |
| Normal role description: | May play a role in transcription regulation and was suggested to act as a tumour suppressor. Translocation in myeloid malignancies resulting in a fusion protein with altered transcription factor acitivity. |