Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARHGEF5 |
| Gene Name: | ARHGEF5 |
| Protein Full Name: | Rho guanine nucleotide exchange factor 5 |
| Alias: | TIM |
| Mass (Da): | 176799 |
| Number AA: | 1597 |
| UniProt ID: | Q12774 |
| Locus ID: | 7984 |
| COSMIC ID: | ARHGEF5 |
| Gene location on chromosome: | 7q35 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.59 |
| Normal role description: | Involves in Rho-family signalling cascade and interacts with RAC1 and CDC42. Alternate splicing of ARHGEF5 has been demonstrated in breast tumors suggesting that ARHGEF5 functions as a tumour promoter. |