Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Cdc20 |
| Gene Name: | CDC20 |
| Protein Full Name: | Cell division cycle protein 20 homolog |
| Alias: | p55CDC |
| Mass (Da): | 54723 |
| Number AA: | 499 |
| UniProt ID: | Q12834 |
| Locus ID: | 991 |
| COSMIC ID: | CDC20 |
| Gene location on chromosome: | 1p34.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19806 |
| Percent of cancer specimens with mutations: | 0.32 |
| Normal role description: | CDC20 is a ubiquitin ligase activator. Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C). During anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Overexpression of CDC20 has been reported in a multitude of tumors. |