Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MERTK |
| Gene Name: | MERTK |
| Protein Full Name: | Tyrosine-protein kinase Mer |
| Alias: | C-mer; C-mer proto-oncogene tyrosine kinase; EC 2.7.10.1; Kinase Mer; Mer; MERK; MerTK; Proto-oncogene tyrosine-protein kinase MER precursor; Receptor tyrosine kinase MerTK; RP38 |
| Mass (Da): | 110249 |
| Number AA: | 999 |
| UniProt ID: | Q12866 |
| Locus ID: | 10461 |
| COSMIC ID: | MERTK |
| Gene location on chromosome: | 2q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20620 |
| Percent of cancer specimens with mutations: | 0.95 |
| Normal role description: | MERTK is a protein-tyrosine kinase. MERTK has been shown to play a role in several oncogenic mechanisms, including: angiogenesis, migration and invasion, and cell survival signalling. |