Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTPN13 |
| Gene Name: | PTPN13 |
| Protein Full Name: | Tyrosine-protein phosphatase non-receptor type 13 |
| Alias: | APO-1/CD95 (Fas)-associated phosphatase; EC 3.1.3.48; FAP1; FAP-1; Fas-associated phosphatase-1; Fas-associated protein-tyrosine phosphatase 1; PNP1; Protein tyrosine phosphatase 1E; Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTN13; PTP1E; PTP-BAS; PTP-BL; PTP-E1; PTPL1; PTPLE; Tyrosine-protein phosphatase non-receptor type 13 |
| Mass (Da): | 276906 |
| Number AA: | 2485 |
| UniProt ID: | Q12923 |
| Locus ID: | 5783 |
| COSMIC ID: | PTPN13 |
| Gene location on chromosome: | 4q21.3 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19874 |
| Percent of cancer specimens with mutations: | 1.46 |
| Normal role description: | PTPN13 is a protein-tyrosine phosphatase. It negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. Loss of function mutations described in colorectal tumors. However, it is also possible that PTPN13 may function as a tumour promoter by inhibiting Fas apoptosis in other cell systems. |