Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRAP1 |
| Gene Name: | TRAP1 |
| Protein Full Name: | Heat shock protein 75 kDa, mitochondrial |
| Alias: | Hsp75; TRAP-1; Tumor necrosis factor type 1 receptor-associated protein |
| Mass (Da): | 80110 |
| Number AA: | 704 |
| UniProt ID: | Q12931 |
| Locus ID: | 10131 |
| COSMIC ID: | TRAP1 |
| Gene location on chromosome: | 16p13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.53 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | TRAP1 is a chaperone protein that may be associated with the TNF receptor and play a role in the signalling cascade, including upregulating genes involved in cell cycle, cell motility, cell survival and metastasis. It may also exert ATPase activity. |