Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NFATC3 |
| Gene Name: | NFATC3 |
| Protein Full Name: | Nuclear factor of activated T-cells, cytoplasmic 3 |
| Alias: | NFAC3; NF-AT4; NFATC3; NF-ATc3; NFATx; NFC3; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4 |
| Mass (Da): | 115594 |
| Number AA: | 1075 |
| UniProt ID: | Q12968 |
| Locus ID: | 4775 |
| COSMIC ID: | NFATC3 |
| Gene location on chromosome: | 16q22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19745 |
| Percent of cancer specimens with mutations: | 0.76 |
| Normal role description: | NFATC3 regulates gene expression such as actiavtion, elimination and cytokine production T cells and immature thymocytes. Loss of express in mice induced by virus have lead to increased rate of developing T-cell lymphoma due to dysregulation of signalling within T cells. |